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One of the main causes of ankylosing spondylitis is the presence of a gene called HLA-B27 as nearly 90% of the people who develop ankylosing spondylitis gave this gene

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PubMed , Scott, William K., et al

Integrated transcriptomic and metabolomic analyses in this study revealed that periodontitis reprograms intracellular glutathione (GSH) metabolism in BM neutrophils, facilitating their N1 polarization